chronic liver
Research Topic
Language: English
This is a research topic created to provide authors with a place to attach new problem publications.
Research problems linked to this topic
- Drug-induced liver injury (DILI) is a significant challenge to clinicians, drug developers, as well as regulators.
- Fibrosis is an underlying cause of cirrhosis and hepatic failure resulting in end stage liver disease with limited pharmacological options.
- Acetaminophen (APAP) overdose causes hepatocytes necrosis and acute liver failure.
- Acute liver injury is a short-term burst of liver cell damage, which has many causes and complex mechanisms.
- Fibrosis progression is the common consequence of most chronic liver diseases.
- Post-operative bile leak (BL) and post hepatectomy liver failure (PHLF) are the major potential sources of morbidity among patients undergoing liver resection.
- It is estimated that liver diseases are among the top ten killer diseases in India, causing deaths every year.
- Steatorrhea is a common feature of chronic liver disease.
- Primary sclerosing cholangitis (PSC) is a rare, immune-related disease characterized by chronic biliary inflammation and fibrosis of the intra and/or extra-hepatic biliary tree, leading to end-stage liver disease and biliary cancer.
- Oxidative stress is the leading cause of most liver diseases, such as drug-induced liver injury, viral hepatitis, and alcoholic hepatitis caused by drugs, viruses, and ethanol.
- Chronic liver disease with progression to decompensated cirrhosis and its associated complications, including hepatic encephalopathy, spontaneous bacterial peritonitis, and sepsis, is a leading cause of mortality and morbidity.