liver disease
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- Massive ascites and hepatorenal syndrome (HRS) are frequent complications of liver cirrhosis.
- Wilson disease is a rare but important disorder of copper metabolism, with a failure to excrete copper appropriately into bile.
- Autoimmune hepatitis (AIH) is a relatively rare cause of hepatic dysfunction, which can lead to acute liver failure (ALV) and cirrhosis if not treated.
- Hepatobiliary disorders are common problems during pregnancy, causing significant morbidity and mortality in both mother and fetus.
- Biliary atresia is a common disease in neonates which causes obstructive jaundice and progressive hepatic fibrosis.
- Tissue-specific deletion of the gene for NADPH-cytochrome P450 (P450) reductase (CPR), the essential electron donor to all microsomal P450 enzymes, in either liver or intestine, leads to upregulation of many P450 genes in the tissue with the Cpr deletion.
- The Budd-Chiari syndrome (BCS) is a rare disorder due to chronic liver disease (CLD), which is caused by the obstruction of hepatic venous outflow that can be located at any place from the small hepatic venules up to the entrance of the inferior vena cava (IVC) into the right atrium.
- Hepatitis A virus usually causes acute viral hepatitis (AVH) in the paediatric age group with a recent shift in age distribution and disease manifestations like acute liver failure (ALF).