disease alzheimer
Research Topic
Language: English
This is a research topic created to provide authors with a place to attach new problem publications.
Research problems linked to this topic
- The most progressive neurodegenerative disease so far we know are Alzheimer's disease (AD) and Parkinson's disease (PD).
- Neuropsychiatric symptoms (NPS) are the leading cause of the social burden of dementia but their role is underestimated.
- Alzheimer's disease (AD) brains contain neurofibrillary tangles (NFTs) composed of abnormally hyperphosphorylated tau protein.
- Ischemic neuronal disintegration of the brain tissue is a main risk factor for the development of a vascular dementia (VD).
- The accumulation and aggregation of phosphorylated tau proteins in the brain are the hallmarks for the onset of Alzheimer's disease (AD).
- As dementia progresses, symptoms and concerns increase, causing considerable distress for the person and their caregiver.
- The increasing number of elderly people affected by dementia in Taiwan has made dementia care a crucial issue of concern.
- Type 2 diabetes is a risk factor for Alzheimer's disease (AD), and AD brain shows impaired insulin signalling.
- Although many Alzheimer's disease (AD) patients have a family history of the disease, it is rarely inherited in a predictable way.
- We describe a new mutation causing Alzheimer's disease (AD) in presenilin-1 (N135D) that is at the homologous site to the presenilin 2 mutation (N141I) in Volga German kindreds.
- Protein misfolding and aggregation is a key event in diseases like Alzheimer's disease (AD) or Parkinson's disease (PD) and is associated with neurodegeneration.
- Amnestic mild cognitive impairment (MCI) has been defined as a precursor to Alzheimer's disease (AD), although it is sometimes difficult to identify which persons with MCI will eventually convert to AD.
- Cognitive decline and dementia are major public health social problems, suggesting the specific need to provide research into risk factors for cognitive decline as priority topic.
- Fronto-temporal dementia (FTD) is a common type of presenile dementia, characterized by a heterogeneous clinical presentation that includes three main subtypes: behavioural-variant FTD, non-fluent/agrammatic variant primary progressive aphasia and semantic variant PPA.
- Cerebrovascular disease underpins vascular dementia (VaD), but structural and functional changes to the cerebral vasculature contribute to disease pathology and cognitive decline in Alzheimer's disease (AD).
- As Alzheimer's disease progresses, neuropsychiatric symptoms, particularly those common in the middle stages of the disease can be increasingly stressful for family caregivers.