parkinsonism
Research Topic
Language: English
This is a research topic created to provide authors with a place to attach new problem publications.
Research problems linked to this topic
- Parkinson's disease (PD) is a neurological disease that affects the motor system.
- Parkinson's disease (PD) is a frequent neurodegenerative disease with a premotor phase that lasts several years.
- Parkinson disease (PD) is one of the most common neurologic conditions in the United States, with an estimated prevalence of 500,000.
- Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy are brain disorders characterised by intracellular α-synuclein deposits.
- Fatigue is a very common non-motor symptom in Parkinson disease (PD) patients.
- Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism.
- Gait disturbance and postural instability (PI) are among the most medication-refractory motor symptoms of Parkinson's disease (PD).
- Lewy body dementia (LBD), including dementia with Lewy bodies (DLB) and Parkinson's disease dementia, is a common form of neurodegenerative dementia.
- Progressive supranuclear palsy (PSP) is a syndrome characterized by progressive parkinsonism with early falls due to postural instability, typically vertical gaze supranuclear ophthalmoplegia, pseudobulbar dysfunction, neck dystonia and upper trunk rigidity as well as mild cognitive dysfunction.
- The major motor disturbances in Parkinson's disease are thought to be caused by overactivity of the GABAergic internal segment of the globus pallidus (GPi), which acts as a brake on the motor thalamus and the cortical motor system to produce the slowness, rigidity, and poverty of movement characteristic of parkinsonian states.
- Multiple-system atrophy (MSA) is a neurodegenerative disease characterized by autonomic failure with various combinations of parkinsonism, cerebellar ataxia, and pyramidal dysfunction.
- Parkinson's disease is a common motor disorder that not only leads to motor symptoms but also autonomic dysregulation, mental changes, sensory disturbances, and sleep disorders such as increased daytime sleepiness and sleep fragmentation.
- Loss-of-function mutations in the gene encoding the mitochondrial PTEN-induced putative kinase 1 (PINK1) are a major cause of early-onset familial Parkinson's disease (PD).
- Parkinson disease (PD) is a progressive neurodegenerative disease that affects peripheral organs as well as the central nervous system and involves a fundamental role of neuroinflammation in its pathophysiology.