amyloidosis
Research Topic
Language: English
This is a research topic created to provide authors with a place to attach new problem publications.
Research problems linked to this topic
- AL amyloidosis is a condition in which plasma cell neoplasm brings about consequent abnormal amyloid deposition, and it has a poor prognosis.
- Amyotrophic lateral sclerosis (ALS) is a progressive neurological disorder caused by degeneration of the motor neurons in cortex, brainstem and spinal cord.
- One of the pathological changes of Alzheimer's disease is the deposit of β/A4 protein, which is derived from Alzheimer amyloid precursor protein (APR).
- Amyloidosis is an increasingly recognized cause of heart disease, caused by the deposition of misfolded protein within the heart.
- Glomerular injury and proteinuria are important pathophysiological features of chronic kidney disease.
- Amyloidosis is a heterogeneous group of diseases that may take on many forms and involve different organ systems.
- Extracellular deposition of amyloid-β (Aβ) aggregates in the brain represents one of the histopathological hallmarks of Alzheimer's disease (AD).
- Transthyretin familial amyloid polyneuropathy (TTR-FAP) is a fatal clinical disorder characterized by extracellular deposition of abnormal fibrils derived from misfolded, normally soluble transthyretin (TTR) molecules.
- In neurodegenerative diseases, a wide range of amyloid proteins or peptides such as amyloid-beta and α-synuclein fail to keep native functional conformations, followed by misfolding and self-assembling into a diverse array of aggregates.
- People with Amyotrophic Lateral Sclerosis (PwALS) in the advanced phase are critically affected by an almost total loss of mobility and severe communication problems.