thrombocythemia
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- Pulmonary thromboembolism (PTE) is the major cause of maternal death in the UK.
- Arterial and venous thromboembolic disorders remain the leading cause of death in most of the develop countries.
- Acute idiopathic (immune) thrombocytopenic purpura (ITP) in childhood is an uncommon, self-limiting disease.
- Glanzmann thrombasthenia (GT) is an autosomal recessive bleeding disorder characterized by deficient or dysfunctional glycoprotein (GP) IIb/IIIa compexes.
- Most cases of fetal and neonatal alloimmune thrombocytopenia (FNAIT) are caused by maternal alloantibodies against human platelet antigen-1a (HPA-1a).
- Essential thrombocythemia is a clonal myeloproliferative disorder that causes thrombocytosis.
- Device thrombosis is a devastating complication of left ventricular assist devices.
- Paroxysmal nocturnal haemoglobinuria (PNH) is a clonal haemolytic disease with a propensity for causing thrombotic complications.
- Cerebral sinovenous thrombosis (CSVT) is a rare disease with potential catastrophic consequences.
- With an extremely high morbidity and mortality, pulmonary thromboembolism (PTE) has greatly impacted the life quality of patients survived a thromboembolic event.
- Acquired thrombotic thrombocytopenic purpura (aTTP) is a rare hematological emergency that is characterized by microangiopathic hemolytic anemia (MHA), thrombocytopenia, fever, and multiorgan failure due to autoimmune-mediated deficiency in ADAMTS-13 activity.
- Heparin-induced thrombocytopenia (HIT) is a prothrombotic and potentially devastating complication of heparin therapy due to formation of platelet-activating antibodies against complexes of platelet factor 4 and heparin.
- Primary anti-phospholipid syndrome (APS) is a thrombophilic state characterized by recurrent arterial and venous thrombosis, recurrent pregnancy loss, and the presence of circulating anti-phospholipid antibodies that may be responsible for thrombophilia and pregnancy morbidity.
- Thrombotic microangiopathies (TMAs) represent a heterogeneous group of diseases characterized by a microangiopathic hemolytic anemia, peripheral thrombocytopenia, and organ failure of variable severity.