metastasis
Research Topic
Language: English
This is a research topic created to provide authors with a place to attach new problem publications.
Research problems linked to this topic
- Bone is a common metastatic site of cancer.
- Bone metastasis is common in late-stage breast cancer patients and leads to skeletal-related events that affect the quality of life and decrease survival.
- The primary cause of cancer-related death from solid tumors is metastasis.
- Bone metastasis is an incurable complication of breast cancer affecting 70-80% of advanced patients.
- In breast cancer, most of the patients who died, have developed bone metastasis as disease progression.
- Hematogenous metastatases are the most common adult central nervous system malignancies.
- Chondrosarcoma is a type of highly malignant tumor with a potent capacity to invade locally and cause distant metastasis.
- Brain metastases (BM) are a devastating consequence of advanced breast cancer (BC).
- The inability to sensitively detect metastatic cells in preclinical models of cancer has created challenges for studying metastasis in experimental systems.
- Bone is the third leading site of metastatic disease, after the lung and liver.
- Leptomeningeal metastasis (LM) is a lethal complication in which cancer metastasizes to the meninges.
- Metastatic cancer cells cross endothelial barriers and travel through the blood or lymphatic fluid to pre metastatic niches, leading to their colonisation.
- In tumor metastasis, multicellular aggregates of tumor cells form and disseminate into the blood or lymph vessels from the tumor mass, following the formation of tumor cell emboli in distant vessels.
- Ovarian cancer metastasizes via direct seeding, whereby cancer cells shed from the primary site, resist cell death in the peritoneal cavity, then metastasize to peritoneal organs.
- The liver and lung are the organs most commonly affected by metastasis in colorectal cancer (CRC), and the interaction of chemokines and chemokine receptors (CKRs) plays an important role in the metastatic process.