cancer colorectal
Research Topic
Language: English
This is a research topic created to provide authors with a place to attach new problem publications.
Research problems linked to this topic
- Lymph node metastasis is one of the most important prognostic factors for survival of patients with gastric cancer (GC) after surgical resection.
- While the incidence of gastric cancer has decreased worldwide in recent decades, the incidence of signet-ring cell carcinoma (SRCC) is rising.
- Colorectal cancer (CRC) is one of the most commonly diagnosed cancers and it is ranked the third most common globally.
- Distant metastasis is the main cause of colorectal cancer (CRC)-related mortality, but the underlying mechanism remains largely elusive.
- Patients with Lynch syndrome have a high risk of colorectal cancer (CRC).
- Acute gastrointestinal obstruction due to colorectal cancer occurs in 7-30% of cases and is an abdominal emergency that requires urgent decompression.
- PIK3CA, the catalytic subunit of PI3K, is mutated in many different tumors, including colorectal cancer (CRC).
- Like many other types of cancer, colorectal cancer (CRC) develops through multiple pathways of carcinogenesis.
- Despite significant advances in primary management of rectal cancer, local recurrence, although increasingly uncommon, presents a therapeutic challenge.
- Surgical treatment of recurrent rectal tumors is a challenge for cancer surgeons.
- Colorectal cancer (CRC) results from the progressive accumulation of genetic and epigenetic alterations that lead to the transformation of normal colonic mucosa to adenocarcinoma.
- Since over 70% of colorectal cancers (CRC) occurs in patients at least aged 65 years old, it can be considered a disease of elderly people and is one of major cause of morbidity and mortality at this age.
- Colorectal cancer develops in a multi-step manner from normal epithelium, through a pre-malignant lesion (so-called adenoma), into a malignant lesion (carcinoma), which invades surrounding tissues and eventually can spread systemically (metastasis).
- For more than 40 years, fluorouracil has been the mainstay of treatment for advanced colorectal cancer, the second leading cause of cancer-related death in the United States.
- Colorectal cancer (CRC) is driven by genetic alterations that result in constitutive activation of oncogenic transcription factors (eg β-catenin, MYC) and of mitogenic signaling and.
- The Hereditary Non-Polyposis Colorectal Cancer (HNPCC), also known as Lynch Syndrome (LS), is an autosomal dominantly inherited cancer syndrome that accounts for about 3-5% of all colorectal cancers (CRCs).