breast cancer
Research Topic
Language: English
This is a research topic created to provide authors with a place to attach new problem publications.
Research problems linked to this topic
- The Philippines has the highest reported incidence of breast cancer (BC) in Southeast Asia, with a rate of 47.
- The major portion of hereditary breast cancer still remains unexplained, and many susceptibility loci are yet to be found.
- Cancer is the leading cause of death for Asian Americans, and breast cancer is the leading cancer diagnosed among Asian American women.
- Studies on ER/PR/HER2 in breast cancer from Sub Saharan Africa (SSA) are fraught with inconsistencies in the prevalence of hormone receptor status.
- Breast cancer begins as a localized disease, but can spread to other sites within the body.
- Breast cancer is a genetically and clinically heterogeneous disease.
- Inflammatory breast cancer (IBC) is a rare but often fatal disease.
- A major problem in current standard therapy for breast cancer is systemic toxicity.
- HER2 detection is important for breast cancer (BC) treatment and prognosis, but the detection methods currently used have some disadvantages.
- Metaplastic breast carcinomas (MBCs) are a rare and heterogeneous group of breast carcinomas.
- Trastuzumab is a key component of adjuvant therapy for stage I to III human epidermal growth factor receptor 2 (HER2)-positive breast cancer.
- The diagnosis of breast cancer combines the trauma of managing a potentially fatal disease with a radical assault on the body image of the patient.
- Drug resistance is the main cause for therapeutic failure and death in breast cancer.
- Hormone replacement therapy (HRT) has been considered one of the main risk factors for breast cancer.
- Skin toxicity is a frequent side effect of radio and chemo-treatments in patients treated for breast cancer after conservative surgery.
- Breast cancer is a complex and heterogeneous disease.
- Triple negative breast cancer (TNBC) often presents as high grade, poorly differentiated tumors resulting in a more aggressive disease for which accurate and timely diagnosis is critical to treatment selection or clinical trial enrollment.
- While the events leading to breast cancer development are not fully understood, a pre-invasive lesion, ductal carcinoma in situ (DCIS), is recognised as the main precursor of invasive disease.
- The estrogen-signaling pathway plays an important role in the pathophysiology of breast cancer, and the sulfotransferase 1A (SULT1A) family has been found to be both downstream targets of tamoxifen and a risk factor of breast cancer.