cell death
Research Topic
Language: English
This is a research topic created to provide authors with a place to attach new problem publications.
Research problems linked to this topic
- Caspases, the intracellular cysteine proteinases, play a central role in the process of programmed cell death.
- Less than 50% of patients with melanoma respond to anti-programmed cell death protein 1 (anti-PD-1), and this treatment can induce severe toxicity.
- Aging is an inexorable process in most living organisms that leads to damage accumulation and, consequently, to the loss of cellular homeostasis.
- Neurological diseases are often accompanied by neuronal cell death and subsequent deafferentation of connected brain regions.
- Compared to the normal tissues, cancer cells tend to have higher proliferation rate and often lost their ability to undergo apoptosis.
- Necroptosis is a form of regulated cell death which results in loss of plasma membrane integrity, release of intracellular contents, and an associated inflammatory response.
- Many factors regulate cancer cell apoptosis, among which Survivin has a strong anti-apoptotic effect and PHLPP is a tumor suppressor gene that can induce significant apoptosis.
- Apoptosis, a form of programmed cell death, is a critical defence mechanism against the formation and progression of cancer and acts by eliminating potentially deleterious cells without causing such adverse effects, as inflammatory response and ensuing scar formation.
- Ferroptosis is a new form of programmed cell death characterized by intracellular iron-dependent accumulation of lipid peroxide and primarily associated with iron metabolism, glutathione-dependent pathway, and coenzyme Q10-dependent pathway.