organ transplantation
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- Respiratory virus infections are becoming increasingly appreciated causes of morbidity and mortality in bone marrow transplant recipients.
- Primary Graft Dysfunction (PGD) is one of the primary causes of 30 day mortality after heart transplantation.
- Immunosuppression in kidney transplant recipients with decreased graft function and severe histological vascular changes can be particularly challenging.
- The scarcity of grafts remains to be the major limitation in lung transplantation.
- Urologic complications in kidney transplantation have an incidence ranging from 3% to 20%, representing an important cause of organ loss.
- In the United States, live organ donation can be a costly and burdensome undertaking for donors.
- Cancer, particularly skin cancer and lymphoma, is a complication of post-transplantation immunosuppression.
- Lung transplant recipients require life-long profound immunosuppression, making them prone to respiratory tract infections (RTIs), in particular viral infections, during the winter season.
- Immunosuppressive medications are critical for maintenance of graft function in transplant recipients but can represent a substantial financial burden to patients and their insurance carriers.
- Humoral sensitization to antigens of the human leukocyte antigen and ABO systems remains one of the largest barriers to further expansion in renal transplantation.